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 		     Anatomy of Gene Regulation
A Three-dimensional Structural Analysis
Cambridge University Press - (ISBN-13: 9780521804745)
Published January 2003

  
 
  Price:     £ 40.00

    
  Author(s):     Panagiotis A.Tsonis
University of Dayton, Ohio

    
  Description:     No longer simple line drawings on a page, molecular structures can now be viewed in full-figured glory, often in color and even with interactive possibilities. Anatomy of Gene Regulation is the first book to present the parts and processes of gene regulation at the three-dimensional level.  Vivid structures of nucleic acids and their companion proteins are revealed in full-color, three-dimensional form.  Beginning with a general introduction to three-dimensional structures, the book looks at the organization of the genome, the structure of DNA, DNA replication and transcription, splicing, protein synthesis, protein and ultimate death. Throughout, the text employs a discussion of genetics and structural mechanics. The concise and unique synthesis of information will offer insight into gene regulation, and into the development of methods to interfere with regulation at diseased states. This textbook and its accompanying Web site are appropriate for both undergraduate and graduate students in genetics, molecular biology, structural biology, and biochemistry courses.

• The first textbook to present gene regulation at the three-dimensional level • More than 250 color images • Accompanying Web site complements book.

    
  Contents List:     Preface 1. A general introduction to 3-D structures; 2. The higher organization of the genome; 3. Structure of DNA and telomeres;  4. DNA replication; 5. Transcription in prokaryotes; 6. Transcription in eukaryotes; 7. Splicing; 8. Modifications of mRNA; 9. Compartmentalization of transcription; 10. Protein synthesis; 11. The birth and death of proteins; Index.

    
  Reviews:    
 '… Beautiful and informative three-dimensional images of the nucleosomes, RNA and DNA polymerase and the ribosome. Years of genetic and biochemical data spring to life when mapped onto these structures, and future experiments can be designed with much greater precision. Many of us who teach molecular biology at the undergraduate or graduate level have tried to convey this excitement by incorporating structures into our teaching. What might otherwise be dry descriptions of protein interactions or catalytic steps take on greater clarity and tangibility when students can see the molecules. Pangiotis Tsonis has compiled and summarized a great deal of structural information in his new book entitled Anatomy of Gene Regulations. It's a terrific idea and a laudable effort. " Nature Structural Biology.

'So this book presents a very wide-ranging coverage of three-dimensional structural aspects only in a concise and attractive format with very readable text… I enjoyed this book as a handy source to dip into for structural insights and for the author's obvious pleasure in communicating these to his audience. " Heredity.

   
  Publisher:     Cambridge University Press.