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Pathway Analysis and Optimization in Metabolic
Engineering Cambridge University Press - (ISBN-13: 9780521800389) Published December 2002 |
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| Price: |
£ 75.00 |
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| Author(s): |
Eberhard O.Voit Medical University of South Carolina |
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| Description: |
Facility in the targeted manipulation of the genetic and metabolic
composition of organisms, combined with unprecedented
computational power, is forging a niche for a new subspecialty of
biotechnology called metabolic engineering. This book introduces
researchers and advanced students in biology and engineering to methods
of optimizing biochemical systems of biotechnological relevance.It
examines the development of strategies for manipulating metabolic
pathways, demonstrates the need for effective systems models, and
discusses their design and analysis, while placing special emphasis on
optimization.The authors propose power-law models and methods of
biochemical systems theory toward these ends. All concepts are derived
from first principles, and the text is richly illustrated with graphs
and numerous examples throughout. Special features include: • both
nontechnical and technical introductions to models of biochemical
systems • a review of basic methods of model design and analysis •
concepts of optimization • detailed case studies Biotechnologists will
find this introductory book a highly valuable reference, as will other
scientists and engineers interested in biological systems. • Covers a topic of great relevance to recent advances in biotechnology • Discusses complex concepts with clarity, further enhanced by illustrations, examples, and case studies • Both authors are well-respected experts in the field of analysis and modeling of biochemical systems. |
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| Contents List: |
Preface 1. Target: a useful model; 2. Methods of biochemical
systems theory; 3. A model of citric acid production in the mold
Aspergillus niger; 4. Optimization methods; 5. Optimization of
biochemical systems; 6. Optimization of citric acid production in
Aspergillus niger; 7. Maximization of ethanol and carbohydrate
production in Saccharomyces cerevisiae; 8. Conclusions; Author index;
Subject index. |
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| Publisher: | Cambridge University Press. | |||||||