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Aplastic Anemia
Pathophysiology and Treatment
Cambridge University Press - (ISBN-13: 9780511036255)
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Price:
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$ 144.00
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Author(s):
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Hubert Schrezenmeier
Freie University Berlin
Andrea Bacigalupo
Ospedale San Martino, Genoa
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Description:
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This book takes account of the most recent findings in laboratory
research and clinical trials to provide a comprehensive and up-to-date
reference on the path physiology, epidemiology, diagnosis and treatment
of acquired and inherited aplastic anemia. As well as a detailed
overview of the path physiology of the disease, the international team
of authors cover all aspects of management, including the established
approaches of bone marrow transplantation and immunosuppressive
treatment, new approaches such as the use of hematopoietic growth
factors and escalated immunosuppression, and controversial issues such
as stem cell transplantation.Also included is an important international consensus
document on treatment, and a final section concentrates on the inherited
syndrome Fanconi’s anemia. Detailed treatment guidelines are
given, making this the definitive resource for hematologists and other
clinicians involved in the management and supportive care of patients
with aplastic anemia. Scientists interested in bone marrow failure will
also find this an invaluable reference.
• Written by a team of expert authors from Europe, North America and
Japan • Makes use of the most recent research findings in basic science
and clinical trials • The first book on aplastic anemia to have
such an emphasis on treatment.
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Contents List:
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Part I. Pathophysiology of Acquired Aplastic Anemia: 1. Stem cell defect
in aplastic anemia JCW Marsh and NG Testa; 2. Cytokine abnormalities in
aplastic anemia S. Kojima; 3. Role of T-lymphocytes and apoptosis
in pathophysiology of aplastic anemia S. Nakao; 4. Role of
apoptosis in pathophysiology of aplastic anemia FM Gibson, NJ Philpott,
JCW Marsh and EC Gordon-Smith; 5. Interrelation between aplastic anemia
and paroxysmal nocturnal hemoglobinuria G. Partner, J.-Y. Mary, H.
Schrezenmeier and E. Gluckman; 6. Aplastic anemia and other
clonal disorders A. Raghavachar; Part II. Epidemiology and Clinical
Features of Acquired Aplastic Anemia: 7. Epidemiology and etiology
of aplastic anemia H. Heimpel; 8. Clinical presentation, natural course
and prognostic factors P. Marin-Fernandez; Part III. Treatment of
Acquired Aplastic Anemia: 9. Supportive treatment of patients with
severe aplastic anemia P. Ljungman; 10. Immunosuppressive
treatment of aplastic anemia A. Bacigalupo, H. Schrezenmeier and A.
Tichelli; 11. Role of cytokines in the treatment of aplastic anemia H.
Schrezenmeier; 12. HLA-identical sibling bone marrow transplantation to
treat severe aplastic anemia SR McCann, JR Passweg, R. Storb and HJ Deeg;
13. Alternative donor bone marrow transplantation for severe acquired
aplastic anemia JM Hows, JV Stone and BM Camitta; 14. Treatment of
children with acquired aplastic anemia A. Locasciulli;15.
Long-term follow up of patients with aplastic anemia A. Tichelli
and G. Partner 16. Guidelines for treatment of aplastic anemia
(international consensus document); Part IV. Fanconi’s Anemia: 17.
Clinical features and diagnosis of Fanconi’s anemia BP Alter; 18.
Genetic basis of Fanconi’s anemia M. Buchwald and M. Carreau; 19.
Treatment of Fanconi’s anemia E. Gluckman, G. Socio and P.
Guardiola; 20. Genetic correction of Fanconi’s anemia JM Liu.
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Reviews:
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'This book provide a comprehensive and up to date concepts on the
pathophysiology, epidemiology, diagnosis and treatment of acquired and
inherited aplastic anemia. The book is an excellent and enjoyable to
read. The amateur who is satisfied with certainty will drive more from
it than the impartial professional seeking and challenge. For the
mahority of doctors and especially human hematologists, the book
succeeds as an example of the precept ‘first do not harm’. Aplastic
Anemia is a super textbook and should be in the library of every
scientist interested in this subject. I would also suggest the
book to medical students. 'Professor Pio Conti.
Aplastic Anemia is a super textbook and should be in the library of
every scientist interested in this subject. I would also suggest
the book to medical students.’ Professor Pio Conti, International
Journal of Immunopathology and Pharmacology.
Aplastic Anemia will be a useful reference work for clinicians who deal
with this disorder and will be a good source of background information
for those conducting basic research on the mechanisms.’ Journal of the
Royal Society of Medicine.
‘This reference is now the most up-to-date specialized reference on this
subject. It will be of interest to and should be read by trainees in
both pediatric and adult hematology and oncology.’ Doody’s Health
Sciences Book Review Journal.
‘Aplastic anemia (AA) is a rare, complex, and often fatal disease that
with appropriate therpy today has a high cure rate.This book is an
excellent review of this disease with special emphasis on the different
therapeutic modalities. It is a must read for all fellows in
hematology/oncology, as well as other physicians taking care of patients
with AA or Fanconi’s anemia. It is also an important resource of
information and will serve as a reference manual well into the new
century.’ Brynjar Vidarsson, Oncology/Karger.
'The book is up to date, and gives clear information on pathogenesis…
this book is highly recommended and will remain valuable for many years
to come. "Jill Hows, Hematological Oncology.
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Publisher:
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Cambridge University Press.
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